HIGHLIGHTS
- who: Karnpob Kanhasut from the ThailandThailand have published the research: Prediction of the structural interface between fibroblast growth factor23 and Burosumab using alanine scanning and molecular docking, in the Journal: Scientific Reports Scientific Reports
- what: Through this model, the authors reconciled the cross-species reactivity of Burosumab against the different species and further designed a 3.7-fold affinity-enhanced variant of Burosumab. The study provides key insights of the interaction and highlighted the underlying determinants of affinity and specificity of Burosumab, which can be used for rational engineering.
- how: Binding results showed . . .
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