Pregestational prediabetes induces maternal hypothalamic–pituitary–adrenal (hpa) axis dysregulation and results in adverse foetal outcomes

HIGHLIGHTS

• What: This study investigated the effects of pregestational prediabetes on maternal function and postnatal offspring development. In the present study, the PD group had a significant increase in HbA1c concentration when compared to the NPD group in Figure 1b. In this study, insulin sensitivity and beta cell function were assessed using the Homeostasis Model assessment (HOMA), showing insulin resistance (HOMA-IR), reduced insulin sensitivity (HOMA-S), and increased beta cell function (HOMA of β-cell function) in the PD group in Table 1. This study evaluated hippocampal GR and MR gene_expressions.
• Who: Mathuli Ngema and collaborators . . .
  

   

  

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