HIGHLIGHTS
- who: Caroline Raynal et al. from the Institut de Génomique Fonctionnelle, Centre National de la Recherche Montpellier, France have published the research work: Pregnane × Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation, in the Journal: (JOURNAL)
- what: Considering the metabolic profile of irinotecan and the tissue distribution of PXR, the authors aimed to assess to what extent PXR could affect metabolism and colon cancer cell response to irinotecan. The authors show that expression of PXR in human colorectal cancer cells led to irinotecan and SN38 chemoresistance through . . .
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