HIGHLIGHTS
SUMMARY
Changes in DNA methylation (DNAm) leading to dysregulation of gene_expression in these cells is a potential mechanism mediating long-term health effects from early life exposure. Ethics Immune mediators, DNAm, and gene_expression Nasal mucosal lining fluid samples were collected at age 4 weeks and 6 years using a synthetic absorptive matrix to assess airway immune mediators. Inflammatory markers in blood was assessed at 6 months of age using highsensitivity immunoassays based on electrochemiluminescence in a multiplex setting30 DNA methylation (Illumina Infinium Methylation EPIC array; Illumina, San Diego, Calif) and gene_expression (RNA sequencing) were assessed . . .
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