Prenatal treatment with egcg enriched green tea extract rescues gad67 related developmental and cognitive defects in down syndrome mouse models

HIGHLIGHTS

• who: Benoit Souchet from the Université Paris-Diderot, Sorbonne Paris Cité, Adaptive Functional Biology, National Centre for Scientific Research have published the paper: Prenatal treatment with EGCG enriched green tea extract rescues GAD67 related developmental and cognitive defects in Down syndrome mouse models, in the Journal: Scientific Reports Scientific Reports of 12/03/2018
• what: Because similar effects were observed in the single gene model (mBACtgDyrk1a) and partial trisomy model (Dp(16)1Yey), the authors propose that DYRK1A overexpression is the main cause of GABAergic over accumulation in DS models and of alteration of the . . .
  

   

  

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