HIGHLIGHTS
- What: __SECTION__ Methods.
- Who: Abbreviations and collaborators from the (UNIVERSITY) have published the article: (2024) 20:645-656 Preparation and preliminary evaluation of tritium-labeled allosteric P2X4 receptor antagonist, in the Journal: (JOURNAL)
SUMMARY
P2X4 receptors belong to the P2X receptor family of ATPactivated ionotropic membrane receptors comprising seven receptor subunits, P2X1-P2X7. To homotrimeric receptors, heterotrimeric receptors exist, e_g P2X2/3 receptors. P2X4 receptor blockade might also be beneficial for the treatment of other types of chronic pain, e_g cancer pain, inflammatory pain, and visceral pain. An upregulation of P2X4 . . .
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