Preparation, characterization, and biological evaluation of a hydrophilic peptide loaded on peg-plga nanoparticles

HIGHLIGHTS

SUMMARY

For a number of therapeutic peptides under development, unfavorable physicochemical and pharmaceutical properties limit their translation to pharmaceuticals. To develop a formulation suitable to efficiently load and release FS10 in PEG-PLGA Nps, both the double emulsion and the nanoprecipitation method were considered. The effect of the different methods and formulation parameters on Nps physicochemical properties (Z-average diameter, polydispersity, ζ-potential), entrapment efficiencies, loading capacities, in_vitro release kinetics, and morphological features, were investigated. The antimicrobial and antibiofilm activity of FS10-PEG-PLGA Nps against S. aureus strains were studied. The effect of the different . . .

 



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