HIGHLIGHTS
- What: Symptoms by presentation site Four studies reported on both disease sites, the mediastinum/head-neck region, and associated symptomology, with one study focusing specifically on intensive care admissions . Assessment of study quality in this systematic review identified possible moderate risk of bias introduced from studies of varying quality. Through this systematic review and meta-analysis of proportions, the authors provide a summary of the prevalence of symptoms and signs associated with childhood and adolescent lymphoma. The authors demonstrate that wellknown clinical features (lymphadenopathy and B-symptoms) are frequently observed at diagnosis but that other symptoms and . . .
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