Presynaptic acetylcholine receptors modulate the time course of action potential-evoked acetylcholine quanta secretion at neuromuscular junctions

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SUMMARY

    The Time Course or Kinetics of the Evoked Acetylcholine Quanta Release Following the activation of motoneuron, acetylcholine (ACh) released from the presynaptic nerve terminals initiates a depolarization of the muscle end plate, which triggers an action potential causing muscle-fiber contraction. Vesicular or "quantal" hypothesis of ACh release introduced by B. Katz presumes that the nerve impulse evokes the release of tens (warm-blooded) to hundreds (cold-blooded) of ACh quanta from the motor nerve terminals at the neuromuscular junction. The time course of ACh quanta release depends differently on the motor nerve stimulation . . .

     

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