Prevalence of estrogen receptor alpha ( esr1 ) somatic mutations in breast cancer

HIGHLIGHTS

• who: JNCI Cancer Spectrum ( et al. from the DepartmentColumbia University Irving Medical Center, New York, NY, USA have published the paper: Prevalence of Estrogen Receptor Alpha ( ESR1 ) Somatic Mutations in Breast Cancer, in the Journal: (JOURNAL)

SUMMARY

Estrogen receptor-positive breast tumors, which initially respond effectively to endocrine therapy, progress due to acquired endocrine therapy resistance, including genomic alterations in estrogen receptor alpha (ESR1). A recent study has suggested that there is a sufficient number of preexisting ESR1 mutations acting as an intrinsic resistance mechanism to warrant primary screening. The authors determined the . . .

 



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