Prevention of anti-hmgcr immune-mediated necrotising myopathy by c5 complement inhibition in humanised mouse model marion carrette laetitia jean rachid zoubairi henri gondé benveniste yves allenbach

HIGHLIGHTS

  • who: Sarah Julien and collaborators from the de Rouen, Rouen, France Salpêtrière University have published the Article: Prevention of Anti-HMGCR Immune-Mediated Necrotising Myopathy by C5 Complement Inhibition in Humanised Mouse Model Marion Carrette Laetitia Jean Rachid Zoubairi Henri Gondé Benveniste Yves Allenbach, in the Journal: Biomedicines 2022, 10, 2036. of 20/08/2022
  • what: The aim of this study was to pre-clinically evaluate the C5 inhibitor zilucoplan in a humanized mouse model of IMNM and to compare its efficacy when used in a preventive manner or therapeutic setting. Muscle strength . . .

     

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