Pridopidine selectively occupies sigma-1 rather than dopamine d2 receptors at behaviorally active doses

HIGHLIGHTS

  • who: C-raclopride . Receptor occupancy and collaborators from the Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands have published the article: Pridopidine selectively occupies sigma-1 rather than dopamine D2 receptors at behaviorally active doses, in the Journal: (JOURNAL)
  • what: This study examined sigma-1R and D2R by the stabilizer (ACR16) at behaviorally relevant doses in living rats.
  • how: The biodistribution VT and BP data were analyzed using ANOVA.
  • future: Future experiments employing sigma-1R knockout animals rather than a pharmacological blocking . . .

     

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