Primary neurons lacking the snares vti1a and vti1b show altered neuronal development

HIGHLIGHTS

  • who: Christian Bollmann from the Department of Chemistry, Bielefeld University, Bielefeld, Germany have published the research: Primary neurons lacking the SNAREs vti1a and vti1b show altered neuronal development, in the Journal: (JOURNAL)

SUMMARY

    The authors are interested in the neuronal function of the ubiquitously expressed Qb-SNAREs vti1a and vti1b. While Vti1a-/- and Vti1b-/- mice are viable Vti1a-/- Vti1b-/- double deficient mice die at birth suggesting a partially redundant function for vti1a and vti1b. As BDNF did not stimulate neurite elongation in Vti1a-/- Vti1b-/- neurons, the authors studied the amounts of TrkB receptor . . .

     

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