HIGHLIGHTS
- who: Chenyu Lu and colleagues from the Department of Biology and Chemistry, College of Sciences, National University of Defense Technology, Changsha, China have published the article: Prime Editing: An All-Rounder for Genome Editing, in the Journal: (JOURNAL)
- how: The results showed that optimization of pegRNA resulted in a 3-4-fold increase in efficiency in several cell lines (HeLa U2OS K562 and primary human fibroblasts) with no increase in off-target effects.
- future: PegRNA engineering should remain the main method to improve PE editing efficiency in the future. Their study pointed out . . .
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