Primitive haematopoiesis in the human placenta gives rise to macrophages with epigenetically silenced hla-dr

HIGHLIGHTS

• who: Jake R. Thomas from the (UNIVERSITY) have published the Article: Primitive haematopoiesis in the human placenta gives rise to macrophages with epigenetically silenced HLA-DR, in the Journal: (JOURNAL) of 31/07/2022
• what: Using in_vitro culture experiments the authors demonstrate that PEMP generate HBC-like cells lacking HLA-DR expression. The authors propose that the dynamics of gene_expression in foetal macrophages, in particular HLA class II expression, can be used to visualise how primitive macrophages are replaced by definitive macrophages across human foetal tissues (Fig 5E,F, Supplementary Fig 10AD)24,27,28 . . .
  

   

  

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