Prmt1, a key modulator of unliganded progesterone receptor signaling in breast cancer

HIGHLIGHTS

• who: Lucie Malbeteau and collaborators from the Universitu00e9 Lyon, Lyon, France have published the research work: PRMT1, a Key Modulator of Unliganded Progesterone Receptor Signaling in Breast Cancer, in the Journal: (JOURNAL)
• what: Mostly based on proximity ligation assays (PLAs) and ChIP-qPCRs, the authors report that PRMT1 interacts within this repressive complex and targets uPR-dependent promoters in hormone-free T47D breast cancer cells. The authors investigated the role of PRMT1 in uPR signaling, in a progesterone- and estrogen-deprived context and intentionally omitted the unliganded ERu03b1 pathway (to make the analysis of uPR . . .
  

   

  

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