Prmt5-mediated regulatory arginine methylation of ripk3

HIGHLIGHTS

• who: Chanchal Chauhan from the (UNIVERSITY) have published the research work: PRMT5-mediated regulatory arginine methylation of RIPK3, in the Journal: (JOURNAL) of 11/Nov/2022
• what: The authors provide the first proof for an arginine dimethylation of RIPK3 as such a modulatory mechanism. Using a RIPK3 rescue model in a RIPK3deficient pancreatic cancer cell line which normally cannot undergo necroptosis, the authors demonstrate that the evolutionary conserved dimethylated arginine residue R486 is important for RIPK3-mediated feedback control on RIPK1 autophosphorylation.
• future: Studies using genetic mouse models will be necessary to reveal . . .
  

   

  

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