Pro-caspase-3 is a major physiologic target of caspase-8*

HIGHLIGHTS

• who: Henning R. Stennicke from the which describes simple substrate competition obeying a Michaelis mechanism under conditions where the concentration of the reporter substrate [S] , [S], and Ks is the apparent binding constant of the reporter substrate to the activatorThe Ks values for the hydrolysis of Ac-DEVD-pNA by caspases, and , were determined to , and , mM, respectively. Culture and Transfection of , Cells-MCF cells were maintained in RPMI , with, % heat-inactivated fetal calf serum supplemented with , mM, glutamine, units/ml penicillin, and , mg/ml streptomycin. The caspase, deficient , line was kindly provided by J. Boothman (University . . .
  

   

  

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