Probing allosteric hsp70 inhibitors by molecular modelling studies to expedite the development of novel combined f508del cftr modulators

HIGHLIGHTS

• who: Roberto Sabbadini and collaborators from the Department of Pharmacy, Section of Medicinal Chemistry, School of Medical and Pharmaceutical Sciences, Department of Experimental Medicine, Section of Biochemistry, University of Genoa, Viale Benedetto XV , have published the paper: Probing Allosteric Hsp70 Inhibitors by Molecular Modelling Studies to Expedite the Development of Novel Combined F508del CFTR Modulators, in the Journal: Pharmaceuticals 2021, 1296 of 10/04/2019
• what: The authors focused on and then better explored compound Ia, whose chemical structure highly resembles the one of the prototype MKT-077. The authors reported, for the first time . . .
  

   

  

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