Probing conformational changes of monomeric transthyretin with second derivative fluorescence

HIGHLIGHTS

  • who: Denisa Jazaj and colleagues from the (UNIVERSITY) have published the paper: Probing conformational changes of monomeric transthyretin with second derivative fluorescence, in the Journal: Scientific Reports Scientific Reports of 30/Nov/2018
  • what: In more generic terms, we have shown how the use of second derivative intrinsic fluorescence spectroscopy allows to determine the distribution of the various conformers of a given tryptophan residue in a given protein.

SUMMARY

    The intrinsic fluorescence of tryptophan residues contained in proteins has been widely used to determine and monitor the structural changes occurring during . . .

     

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