Probing interspecies metabolic interactions within a synthetic binary microbiome using genome-scale modeling

HIGHLIGHTS

• What: Below, the authors provide a brief review of recent advancements in this area. To help address the challenges with experimental studies of microbiomes, this work explores an in-silico approach to probe the interactions within the model M-P coculture. In this work, using M. buryatense 5GB1 - A. platensis as the model system, the authors examine different modeling approaches to identify and understand the emergent synergistic interspecies interactions. The improved dynamic community GEM - DynamiCom To address the limitation associated with DFBA, i.e., no community compartment to enable interspecies interactions, the authors propose an improved dynamic . . .
  

   

  

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