Probing pore constriction in a ligand-gated ion channel by trapping a metal ion in the pore upon agonist dissociation*

HIGHLIGHTS

• who: Ilya Pittel from the Ilya Pittel1, Dvora Witt-Kehati1, Nurit Degani-Katzav1, and Yoav Paas, From the Laboratory of Ion Channels, The Mina and Everard Goodman Faculty of Life Sciences, Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat Gan, Israel Eukaryotic pentameric ligand-gated ion channels (pLGICs) are receptors activated by neurotransmitters to rapidly transport ions across cell membranes, down their electrochemical gradientsRecent crystal structures of two prokaryotic pLGICs were interpreted to imply that the extracellular side of the transmembrane pore constricts to close the channel (Hilf, R. J., and Dutzler, R. (2009) Nature . . .
  

   

  

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