Probing the metabolic network in bloodstream-form trypanosoma brucei using untargeted metabolomics with stable isotope labelled glucose

HIGHLIGHTS

  • who: Darren J. Creek and colleagues from the UNITED STATES have published the paper: Probing the Metabolic Network in Bloodstream-Form Trypanosoma brucei Using Untargeted Metabolomics with Stable Isotope Labelled Glucose, in the Journal: (JOURNAL) of March/16,/2015
  • what: Data from this study demonstrated less than 10% labelling in inositol, and confirmed that the inositol moiety of the lipid headgroup glycerol-phosphoinositol was unlabelled (i.e. not formed by de novo synthesis from glucose, consistent with targeted analyses conducted elsewhere to investigate the origin of inositol in T. brucei ). The authors demonstrate that carbons . . .

     

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