Probing the unfolding pathway of α1-antitrypsin*

HIGHLIGHTS

• who: Ellie L. James from the (UNIVERSITY) have published the paper: Probing the Unfolding Pathway of α1-Antitrypsin*, in the Journal: (JOURNAL) of October/14,/1998
• what: The authors have used a novel technique in which unique cysteine residues were introduced at various positions into a1antitrypsin and fluorescently labeled with N,N*-dimethyl-N-(iodoacetyl)-N*-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)ethylenediamine. From the position of the fluorescence probes, the fluorescence quenching data, and the molecular modeling, the authors show that unfolding of a1-antitrypsin occurs via disruption of the A . . .
  

   

  

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