HIGHLIGHTS
SUMMARY
The homeostatic balance between osteoclastic bone resorption and osteoblastic bone formation is disrupted in bone metastases, and whether the change is dominated by bone resorption or formation depends on the way cancer cells interact with bone stromal cells. As the interaction between cancer and bone cells has been increasingly recognized as a potential therapeutic target, targeting the bone cells in PCa bone metastasis might be a feasible therapeutic approach. In the case of PCa bone metastasis, OBs recruit cancer cells to the bone surface by expressing various cytokines such as interleukin-6 (IL-6 . . .
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