Profiling of the prognostic role of extracellular matrix-related genes in neuroblastoma using databases and integrated bioinformatics

HIGHLIGHTS

SUMMARY

Given this background, this study specifically aimed to use genomic and transcriptomic data deposited in databases to investigate ECM-related genes in NB to identify genes that may predict altered patient prognoses. Despite the paucity of somatic genetic alterations in NB, the presence of genetic alterations with potential oncogenic or unknown roles may also be significant; hence, the mutational profiles of ECM-related genes and their putative links with patient survival were investigated. This meta-analysis found that 12 ECM-related genes correlated with NB patient prognosis based on TARGET expression data in cBioPortal . . .

 



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