HIGHLIGHTS
SUMMARY
Isocitrate dehydrogenase (IDH) mutational status is a strong prognostic criterion affecting the natural history of central nervous system (CNS) diffuse gliomas; this was clearly underlined in the 2016 World Health Organization (WHO) classification of CNS tumors and further stressed in the 2021 edition. IDH-mutant diffuse gliomas represent biologically distinct neoplasms compared to the IDH-wildtype glioblastoma and, for this reason, the WHO 2021 classification restricted the use of the glioblastoma term to this entity, replacing the previous IDH-mutant glioblastoma with the novel astrocytoma, IDH-mutant, grade 4. The more comprehensive analysis was . . .
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