HIGHLIGHTS
- who: Åsa Ehlén from the Research University, UMR3348, Orsay, France have published the research: Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: The authors demonstrate that the two conserved residues S193 and T207 are phosphorylated by PLK1, and that phosphorylated BRCA2-T207 is a bona fide docking site for PLK1. The authors show that BRCA2 pT207 is a docking platform for PLK1 that ensures the efficient interaction of BUBR1 with PP2A phosphatase required for chromosome alignment. The authors propose the following working model (Fig 9g . . .
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