Prospects and feasibility of synergistic therapy with radiotherapy, immunotherapy, and dna methyltransferase inhibitors in non-small cell lung cancer

HIGHLIGHTS

• who: Chen Jie and colleagues from the University of Nebraska Medical Center, United States have published the research work: Prospects and feasibility of synergistic therapy with radiotherapy, immunotherapy, and DNA methyltransferase inhibitors in non-small cell lung cancer, in the Journal: (JOURNAL)
• what: In this review, the authors focus on the regulation of DNA methylation on ICIs resistance and radioresistance in NSCLC and elucidate the potential synergistic effects of DNA methylase inhibitors (DNMTis) in patients treated with iRT. This study demonstrated that immunotherapy inhibited the expression of PD-L1 through promoter hypermethylation, while PD-L1 . . .
  

   

  

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