Prospects for the computational humanization of antibodies and nanobodies

HIGHLIGHTS

  • What: The G-score was later derived from the H-score to account for the effects of the size Humanization methods have evolved from initial chimerization approaches, aiming to reduce non-humanness without compromising functionality.
  • Who: Gemma L. Gordon from the Svar Life Science, France University of Zaragoza, Spain have published the article: Prospects for the computational humanization of antibodies and nanobodies, in the Journal: (JOURNAL)
  • How: This in turn can be used to inform the choice of mutations for humanization.
  • Future: Given the increasing application of nanobodies in the therapeutic . . .

     

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