Protease associated domain of rnf43 is not necessary for the suppression of wnt/β-catenin signaling in human cells

HIGHLIGHTS

• who: Tomasz Radaszkiewicz from the (UNIVERSITY) have published the research: Protease associated domain of RNF43 is not necessary for the suppression of Wnt/β-catenin signaling in human cells, in the Journal: (JOURNAL)
• what: The current experiments shown in Figs 1 and 2 used the overexpression system that produced high RNF43 levels (see Fig 1c). The authors propose that under these conditions RSPO1 treatment inhibits wt RNF43 but not RNF43 ΔPA. Using multiple sets of assays the authors provide evidence that the extracellular PA domain is not essential for RNF43 inhibitory activity in the Wnt/β-catenin . . .
  

   

  

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