Proteasomal degradation of nod2 by nlrp12 in monocytes promotes bacterial tolerance and colonization by enteropathogens

HIGHLIGHTS

• who: Sylvain Normand from the University of s, UPMC Univ Paris, UMR_S, Paris, France, Inserm, UMR_S, Paris, France. have published the paper: Proteasomal degradation of NOD2 by NLRP12 in monocytes promotes bacterial tolerance and colonization by enteropathogens, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors report evidence that NLRP12 promotes bacterial tolerance via degradation of NOD2 through the Ubiquitin-Proteasome Pathway. The authors provide evidence that NLRP12 signaling within the hematopoietic compartment is exploited by C. rodentium in mice as what observed with Salmonella enterica serovar Typhimurium34. Collectively, the authors provide the rational . . .
  

   

  

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