HIGHLIGHTS
- who: David Romano and collaborators from the Systems Biology Ireland, School of Medicine, University College Dublin, Dublin, Ireland Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland Massachusetts General Hospital, Boston, MA, USA Department of Biology/Whitney Laboratory for Marine Bioscience, University of Florida, Gainesville, FL, USA have published the article: Proteasomal down-regulation of the proapoptotic MST2 pathway contributes to BRAF inhibitor resistance in melanoma, in the Journal: (JOURNAL)
- what: The authors show that mutant BRAFV600E binds and inhibits MST2 preventing the activation of MST2-dependent apoptosis. In BRAFi resistant melanoma . . .
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