Protective role of m3 muscarinic acetylcholine receptor in indomethacin-induced small intestinal injury

HIGHLIGHTS

• What: Given the above, this study explored using PAM-369 whether or not M3R protects against NSAIDinduced enteropathy in a mouse model of indomethacin-induced small intestinal injury. In this study using a novel highly selective M3 PAM (PAM-369), the authors showed for the first time that M3R does help maintain the intestinal epithelial barrier function via induction of intestinal epithelial Cl- secretion in a similar manner to EP4R, and potentiation of M3R by M3 PAM ameliorated indomethacin-induced small intestinal injury. This study provided further evidence that M3R is a viable therapeutic target for NSAID . . .
  

   

  

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