HIGHLIGHTS
- who: Aayushi Singh and colleagues from the Department of Chemistry, Iowa State University, Ames, IA, USA have published the research: Protein Conformational Dynamics Underlie Selective Recognition of Thermophilic over Mesophilic Enzyme I by a Substrate Analogue, in the Journal: Biomolecules 2023, 13, 160. of 17/Nov/2019
- what: In general the work demonstrates that conformational dynamics can be exploited in the rational design and optimization of inhibitors with subfamily selectivity. In this contribution, the authors investigate the binding of two non-hydrolysable substrate analogues, allylicphosphonate (cPEP) and sulfoenolpyruvate (SEP), to EIC from E. coli (eEIC . . .
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