Protein design using continuous rotamers

HIGHLIGHTS

  • who: Pablo Gainza et al. from the Department of Computer Science, Duke University, Durham, North Carolina, United States of America, Department of Biochemistry, Duke University Medical Center have published the paper: Protein Design Using Continuous Rotamers, in the Journal: (JOURNAL) of January/12,/2012
  • what: The authors show that allowing continuous side-chain flexibility (which the authors call continuous rotamers) greatly improves protein flexibility modeling. The authors show that in nearly all of the redesigns the sequence found by the continuous-rotamer model is different and has a lower energy than the one found by . . .

     

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