Protein kinase c epsilon overexpression is associated with poor patient outcomes in aml and promotes daunorubicin resistance through p-glycoprotein-mediated drug efflux

HIGHLIGHTS

• who: Rachael Nicholson from the University of California, San Francisco, United States have published the article: Protein Kinase C Epsilon Overexpression Is Associated With Poor Patient Outcomes in AML and Promotes Daunorubicin Resistance Through p-Glycoprotein-Mediated Drug Efflux, in the Journal: (JOURNAL)
• what: The authors examine the frequency of PKCu03f5 dysregulation, as well as the pathophysiological associations and mechanistic contribution of PKCu03f5 misexpression in AML. Initially the authors focused on whether overexpression contributes to the pathogenesis of AML by disrupting myeloid cell growth and differentiation. In the present study, both PKCu03f5 overexpression AML lines . . .
  

   

  

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