HIGHLIGHTS
- who: Attila Varga and collaborators from the Department of Molecular Biology, Semmelweis University, have published the research work: Protein Kinase D3 (PKD3) Requires Hsp90 for Stability and Promotion of Prostate Cancer Cell Migration, in the Journal: Cells 2023, 212 of 12/Dec/2022
- what: Using different prostate cancer cell lines the authors report that Hsp90 ensures PKD3 conformational stability and function to promote cancer cell migration. Although the experiments examined cell migration toward a chemotactic agent, PKD3 is implicated in cell invasion and endothelial-to-mesenchymal transition (EMT) as well through induction of matrix metalloproteinases . . .
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