HIGHLIGHTS
- who: Ting-Wei Mu from the Universidad Nacional de Cu00f3rdoba, Argentina have published the Article: Protein quality control of N-methyl-d-aspartate receptors, in the Journal: (JOURNAL)
- what: The authors focus on missense mutations within the common subunits, GluN1, GluN2A, and GluN2B, which result in reduced surface expression.
SUMMARY
NMDARs are most commonly composed of GluN1 and GluN2 subunits, particularly GluN2A and GluN2B (Monyer et_al, 1994; Paoletti et_al, 2013; Lee et_al, 2014). NMDARs containing GluN2A subunits exhibit three-fold faster decay times and reduced affinity for glutamate than GluN2B-containing . . .
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