HIGHLIGHTS
- who: Ali Bootwala from the Stanford University, United States have published the Article: Protein re-surfacing of E. coli L-Asparaginase to evade pre-existing anti-drug antibodies and hypersensitivity responses, in the Journal: (JOURNAL)
- what: The authors demonstrate the ability of protein Resurfacing, enabled by computational design using structureinformed algorithms, to generate proteins that maintain function while containing high numbers of mutations away from the native sequence. The authors show that the widespread modification of solvent-exposed residues, without the need to identify the epitopes targeted by ADAs a priori, reduces binding by pre . . .
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