Proteolysis dysfunction in the process of aging and age-related diseases

HIGHLIGHTS

  • who: MHC and collaborators from the Merrimack College, United States Complutense University of Madrid have published the article: Proteolysis dysfunction in the process of aging and age-related diseases, in the Journal: (JOURNAL)
  • what: During the inescapable aging process, any changes in the protein quality_control systems, even these subtle ones, may disturb the fragile balance of proper functioning of the proteome.
  • how: In one of the earliest studies (Terman 1995) results indicated that decreased autophagy in aging cells was due to faulty clearance of autophagic vacuoles.
  • future: In a broader perspective . . .

     

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