Proteolysis of vaginally administered bovine lactoferrin: clearance, inter-subject variability, and implications for clinical dosing

HIGHLIGHTS

• who: Thomas P. Hopp from the Metrodora Therapeutics LLC, Brooklyn, NY, USA have published the paper: Proteolysis of vaginally administered bovine lactoferrin: clearance, inter-subject variability, and implications for clinical dosing, in the Journal: (JOURNAL)
• what: None of the VF samples in this study demonstrated a clearcut diagonal precursor/product pattern, suggesting proteolysis does not play a major role in clearance of bLF from VF, compared to washout. This work shows that VF proteases consistently nick bLF in this same region, but at a unique site. The experiments presented in this paper demonstrate that, while . . .
  

   

  

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