HIGHLIGHTS
- who: Nicholas L. Bartelli from the (UNIVERSITY) have published the research work: Proteolytic processing induces a conformational switch required for antibacterial toxin delivery, in the Journal: (JOURNAL) of 12/08/2022
- what: The authors show that proteolysis not only liberates the CdiA-CT for delivery, but is also required to activate the entry domain for membrane translocation.
- how: To test whether the switch occurs with other entry domains the authors examined the CdiA-CTYi29909 from Yersinia intermedia ATCC 29909 which contains an uncharacterized entry domain linked to a toxin domain with predicted deaminase . . .
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