Proteomic analysis of small extracellular vesicles from the plasma of patients with hepatocellular carcinoma

HIGHLIGHTS

SUMMARY

    In recent years, accumulating evidence has suggested that sEVs play important roles in chronic hepatitis, cirrhosis, and liver cancer. sEVs from HCC transport LOXL4 and activate the FAK/Src pathway to facilitate the migration of HCC cells. Due to the close relationship between sEVs and HCC, the authors aimed to explore potential biomarkers from plasma sEVs for the evaluation of HCC. In this study, by comparing the protein expression among the groups of control subjects and patients with HCC, the authors comprehensively identified differentially expressed proteins from sEVs using a label-free quantification method . . .

     

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