Proteomic characterization of the oral pathogen filifactor alocis reveals key inter-protein interactions of its rtx toxin: ftxa

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SUMMARY

    By whole-genome sequencing, the authors discovered that 60% of the F. alocis strains encode a novel repeats-in-toxins (RTX) protein family member, which the authors designated as FtxA. Several of the virulence factors and/or putative virulence-related proteins of F. alocis, including FtxA, are contained within extracellular vesicles released by this organism. To whole-genome sequencing, protein variations in the presence and expression levels among F. alocis strains can be expected. Earlier proteomic work identified protein differences (i.e., in cell-wall anchoring proteins) among 2 of 13 two F. alocis . . .

     

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