Proteomic discovery and validation of novel fluid biomarkers for improved patient selection and prediction of clinical outcomes in alzheimer’s disease patient cohorts

HIGHLIGHTS

• who: Shivangi Awasthi and colleagues from the Need for Standardization In the last few years, we have seen a concerted effort towards establishing accepted protocols, guidelines, and criteria for the testing, reporting, and qualification of mass spectrometry-based proteomic biomarkersMulti-site replication studies are needed for the assessment of intra-lab and inter-lab variability by utilizing the same or alternative proteomic technique and data processing platforms. Research transparency is encouraged through data sharing to scientists, regulators, and clinicians through online repositories, such as ProteomeXchange (Pride [199, ]) and Panorama Public [201]. LC MS AD biomarker discovery research . . .
  

   

  

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