Proteomic mediators of overall cardiovascular health on all-cause mortality

HIGHLIGHTS

SUMMARY

    Taken together, these findings suggest that CVH captures biological age, and this notion is also supported by CVH being associated with the epigenetic clock, one of the widely studied molecular biomarkers of biological age. To address this gap in knowledge, the authors characterized the proteomic profile of CVH in the InCHIANTI Study and investigated whether these proteins mediated the associations between overall CVH and mortality in the cohort participants. For this study, the authors used data from 703 subjects 65 years and older with complete data on plasma_proteins and CVH. Measurement of plasma_proteins was . . .

     

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