Proteomics reveals signal peptide features determining the client speci city in human trap-dependent er protein import

HIGHLIGHTS

• who: Volkhard Helms and colleagues from the Center forSaarland University have published the research: Proteomics reveals signal peptide features determining the client speci city in human TRAP-dependent ER protein import, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors propose that this SP heterogeneity may provide an opportunity for regulation of transport of a subset of precursor polypeptides and may be linked to both TRAP mechanism and CDG etiology.
• how: To validate the TRAP clients the authors conducted independent silencing experiments with TRAPB- targeting siRNAs and subjected three SP-containing candidates . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or E-mail:

  If you don't have an account, you can create one here.