HIGHLIGHTS
- who: Deshaies BMC, Biology and Raymond J, Deshaies from the (UNIVERSITY) have published the Article: Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy, in the Journal: (JOURNAL)
SUMMARY
Genomic alterations may make cancer cells more dependent than normal cells on mechanisms of proteostasis, including protein folding and degradation. In agreement with this, approximately one-third of single chromosomal aneuploidies in yeast cells render them hypersensitive to proteasome inhibitors, and some yeast cells that adapted to aneuploidy were found to contain mutations that derepress the UPS. The proteasome inhibitor bortezomib provided the first . . .
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