HIGHLIGHTS
- who: Yilan Zhen from the Menzies InstituteUniversity of, Portland, OR, USA have published the paper: Protocadherin 15 suppresses oligodendrocyte progenitor cell proliferation and promotes motility through distinct signalling pathways, in the Journal: (JOURNAL) of 18/Oct/2021
- what: The authors show that Pcdh15 is highly expressed by OPCs where it suppresses ERK phosphorylation to negatively regulate OPC proliferation.
- how: As the Akt signalling pathway regulates actin polymerisation in human glioblastoma multiforme cells and human gliomainitiating cells47 and the Akt/mTOR (mechanistic target of rapamycin) pathway is a critical regulator of OPC differentiation including . . .
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